Cutaneous wound healing: recruiting developmental pathways for regeneration

Following a skin injury, the damaged tissue is repaired through the coordinated biological actions that constitute the cutaneous healing response. In mammals, repaired skin is not identical to intact uninjured skin, however, and this disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development. Improving our understanding of the molecular pathways that are involved in these processes is essential to generate new therapies for wound healing complications. Here we focus on the roles of several key developmental signaling pathways (Wnt/β-catenin, TGF-β, Hedgehog, Notch) in mammalian cutaneous wound repair, and compare this to their function in skin development. We discuss the varying responses to cutaneous injury across the taxa, ranging from complete regeneration to scar tissue formation. Finally, we outline how research into the role of developmental pathways during skin repair has contributed to current wound therapies, and holds potential for the development of more effective treatments.     

剩余型直觉模糊推理的三I方法

要本文研究了由左连续三角模所生成的直觉三角模的性质，给出了与直觉三角模相伴随的剩余型直觉蕴涵算子的等价刻画，揭示了直觉模糊蕴涵算子和模糊蕴涵算子的关系．结合模糊推理的三I方法，针对剩余型直觉蕴涵算子，提出直觉模糊推理IFMP问题的三I方法和分解方法，给出两种方法的求解公式，并讨论了它们的还原性，证明了三I方法和分解方法具有良好的还原性．最后提出了IFMP问题的a-三I方法．并给出相应的算例分析．     

Multidimensional Item Response Theory Models with Collateral Information as Poisson Regression Models

Multiple choice items on tests and Likert items on surveys are ubiquitous in educational, social and behavioral science research; however, methods for analyzing of such data can be problematic. Multidimensional item response theory models are proposed that yield structured Poisson regression models for the joint distribution of responses to items. The methodology presented here extends the approach described in Anderson, Verkuilen, and Peyton (2010) that used fully conditionally specified multinomial logistic regression models as item response functions. In this paper, covariates are added as predictors of the latent variables along with covariates as predictors of location parameters. Furthermore, the models presented here incorporate ordinal information of the response options thus allowing an empirical examination of assumptions regarding the ordering and the estimation of optimal scoring of the response options. To illustrate the methodology and flexibility of the models, data from a study on aggression in middle school (Espelage, Holt, and Henkel 2004) is analyzed. The models are fit to data using SAS.     

Distributed Dynamic Navigation for Sensor Networks

Navigation with sensor networks has shown many advantages and great potential in many scenarios.Previous works have mainly focused on selecting the shortest path to navigate an internal user out of an emergency field.However,they did not consider variations of the dangerous areas which usually occur in practical applications.This paper presents an efficient dynamic routing algorithm to successfully guide users to the destination exit.The navigation goal is looking for a safe and short path to enable the user to escape from a dangerous area as fast as possible.Without knowing the locations of the nodes,the user is guided by a sequence of sensor nodes to pass through the dangerous areas.The algorithm ensures the navigation path security by predicting the dynamic changes affecting the navigation path.The performance of this approach is evaluated using extensive simulations to validate its effectiveness.Simulations show that the approach is scalable and performs well in various settings.     

A relocation technique for black-tailed prairie dogs

Relocations of black-tailed prairie dogs have occurred both to save individual prairie dogs from urban development and to reestablish populations that have been extirpated. Unfortunately, however, many past relocation efforts rarely exceeded 40% retention. Many factors have contributed to very low retention rates in past relocation efforts including lack of (1) suitable habitat, (2) proper artificial burrow systems, (3) aboveground acclimation cages or pens, and (4) skilled people conducting the relocations. In an attempt to increase prairie dog relocation success, we developed techniques that are easy to implement, promote high retention, and effectively conserve labor, financial resources, and prairie dog populations. We conducted 3 relocations along the Front Range of Colorado in 2001 and 2002. Relocation techniques we developed resulted in at least 46%-92% retention. Our results suggest that a large percentage of prairie dogs can be retained by (1) ensuring that habitat is suitable, (2) using underground nest chambers modeled after natural nest chambers, (3) acclimating prairie dogs to the release site in large retention pens rather than in retention caps or other small acclimation cages (i.e., rabbit hutch), and (4) providing supplemental feed and water ad libitum to the prairie dogs.     

Demography of the Yarrow's spiny lizard, Sceloporus jarrovii , from the central Chihuahuan Desert

The demography of a population of Yarrow's spiny lizard, Sceloporus jarrovii , was examined from 2004 to 2006 in the canyon Las Piedras Encimadas, located in Gomez Palacio, Durango, México. Lizards were studied using a mark-recapture technique. Reproduction in females occurred between November and May, coinciding with dry conditions. Reproductive activity was highest (percent of females with vitellogenic follicles or embryos) in the middle of the dry season (November and December). Thirteen percent of females reached sexual maturity at an average age of 8.5 months. The population structure was similar in spring and fall, but not in summer. A notable feature of summer, coinciding with the wet season, was the greater number of hatchlings and juveniles. The overall sex ratio did not differ from 1:1. The density of adults varied from 12 to 62 animals ? 0.5 ha –1 . Temperate and arid-adapted populations of S. jarrovii exhibited broad similarity in timing of the reproductive season, whereas factors such as density, growth, age at sexual maturity, and survivorship differed.     

List of Idaho Scolytidae (Coleoptera) and notes on new records

Reported are 105 species of Scolytidae (Coleoptera) from Idaho. About one-third of these are rarely collected, of which 22 species are known from a single locality each. Twelve species reported from Idaho for the first time are: Carphoborus carri Swaine, C. sansoni Swaine, Phloeosinus hoferi Blackman, Conophthorus monophyllae Hopkins, Dryocoetes betulae Hopkins, Ips confuses (LeConte), Pityophthorus absonus Blackman, P. aquilus Blackman , P. blandus Blackman, P. deletus LeConte, P. sculptor Blackman, and Xyleborinus saxeseni (Ratzeburg). Significant extensions of the known distributions in Idaho are reported for seven other scolytids; Alniphagus aspericollis (LeConte), Dendroctonus murrayanae Hopkins, Phloeotribus lecontei Schedl, Procryphalus mucronatus (LeConte), Trypophloeus populi Hopkins, Xyleborus dispar (Fabricius), and X. intrusus Blandford. Xyleborus dispar especially needs study in anticipation that it may become increasingly important in Idaho fruit trees and other woody plants including ornamentals and shade trees.     

Estimates of site potential for Douglas-fir based on site index for several southwestern habitat types

Estimates of site potential for Douglas-fir based on measured site indexes in 450 stands are compared between 10 southwestern habitat types. Significant differences in site potential are found between the habitat types studied.     

Evolutionary divergence in closely related populations of Mimulus guttatus (Scrophulariaceae)

The evolutionary divergence of five closely related populations of the yellow monkey flower. Mimulus guttatus was compared with the length of time the populations could have occupied the site and with the ability of the populations to intercross. Populations from the younger sites were found to be morphologically intermediate to populations from the older sites. Ability to intercross was not correlated with morphological divergence at this stage of evolution.